Celiac Profile

The Celiac Profile uses widely accepted immunologic biomarkers to aid in the diagnosis of Celiac disease (CD). Epidemiologic studies estimate a worldwide prevalence of CD of approximately 1:100 individuals, with a considerable proportion of patients remaining undiagnosed and untreated.1

What is measured on the Celiac Profile?
The Celiac Profile is a blood test that measures important markers to aid in the diagnosis of CD including Total IgA, Anti-Tissue Transglutaminase IgA (tTG IgA) and IgG (tTG IgG), Anti-Deamidated Gliadin IgA (DGP IgA) and IgG (DGP IgG), and reflex Anti-Endomysial IgA (EMA IgA). Along with these results, Genova's unique report configuration provides a simple diagnostic algorithm to aid clinicians in assessing likelihood of disease.

What is Celiac Disease and when should testing be considered?
Celiac disease is defined as an autoimmune enteropathy of the small intestine, caused by exposure to dietary gluten in genetically pre-disposed individuals. In susceptible individuals, gluten ingestion generates an inflammatory reaction predominantly centered in the upper parts of the small intestine. This mucosal injury will eventually reduce the intestinal absorptive area and interfere with uptake of micronutrients.2

Conditions and symptoms associated with Celiac disease1,3,4
Chronic diarrhea with weight loss
Steatorrhea
Postprandial abdominal pain
Bloating
Malabsorption with nutrient deficiencies (iron, B12, calcium)
Irritable bowel syndrome
Elevated liver enzymes
Cerebellar ataxia
Peripheral neuropathy
Type I Diabetes
Autoimmune hepatitis
Autoimmune thyroiditis
Infertility
Dermatitis herpetiformis
Sjogren syndrome
Addison's disease
Parathyroid disorders
Growth hormone deficiency
Primary biliary cirrhosis
Primary sclerosing cholangitis
Testing should be performed while the patient is still on a gluten-containing diet.1 The exception is follow-up testing for monitoring treatment efficacy.